Nocturnal blood pressure rise as a predictor of cognitive impairment among the elderly: a retrospective cohort study

Abstract Background This study investigated the different blood pressure patterns that were evaluated by ambulatory monitoring (ABPM) among elderly patients and explored effect of on cognitive impairment mortality. Methods A total 305 participants aged ?65 years divided into group (CI, n = 130) non-cognitive (NCI, 175) according to MMSE score. All underwent ABPM evaluate possible hypertensive disorder cerebral MRI for evaluation small vessel disease. Follow-up was performed telephone or medical records. The primary outcome all-cause Secondary endpoints major adverse cardiac cerebrovascular events (MACCE). Results Among participants, 130 (42.6%) identified with (CI), average systolic (BP) 127 mmHg diastolic BP 66 mmHg. According ABPM, only 13.1% had a dipper pattern, 45.6% nocturnal rise, while 41.3% non-dipper pattern. Compared NCI patients, CI significantly higher night-time (130.0 ± 18.2 vs. 123.9 15.1, p 0.011), more rise (52.3% 40.6%, 0.042). Nocturnal associated greater white matter hyperintensities (WMH) ( 0.013). After 2.03 follow-up, there 35 deaths 33 cases independently mortality during long-term observation < 0.01). no significant predictive ability in 0.178). Conclusions contributed patients. Not but could increase Controlling based is critical preventing progression dysfunction.